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Conformational analysis reveals the IDP chains would undertake extended conformations in aggregates and would manage mutually perpendicular orientations to minimize inter-chain electrostatic repulsions. The droplet stability is observed to stem from the diminished intra-chain interactions while in the C-terminal locations of αS, fostering inter-chain residue-residue interactions. Intriguingly, a graph idea analysis identifies modest-planet-like networks within droplets throughout environmental conditions, suggesting the prevalence of the consensus conversation styles among the chains. Together these findings counsel a delicate equilibrium concerning molecular grammar and ecosystem-dependent nuanced aggregation conduct of αS.
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